Showing posts with label Genetic. Show all posts
Showing posts with label Genetic. Show all posts

Thursday, March 4, 2010

Genetic links to celiac disease identified: Commentary

Well, I thought we had already established that celiac disease was genetic, but just a couple of days ago it was announced that according to London scientists,  new genetic links to celiac disease have been discovered. An international team of researchers found close to “40 different inherited risk factors which predispose to the disease” (DNA India, boldface added).

We all know that genetics are pretty much entirely responsible for our physical makeup, but I find it interesting that there are so many risk factors that make celiac disease something for which we may be “predisposed.” Just the fact that there are so many millions of people around the world that have CD fascinates me, and it is relatively new disease, historically speaking… rumor even has it that it has something to do with the genetically modified super-gluten that has crept into almost all mainstream food products.

In her book "Harvest for Hope: A Guide to Mindful Eating", famed primatologist Jane Goodall said of genetically modified foods:  "We simply do not know the long-term effects of genetically altering foods" (2006, p. 46).  She also sadly pointed out that "The children of North America have now become the world's lab animals on whom to study the long-term effects of eating GM [genetically modified] products" (p. 62).  We are predisposing ourselves, I often think.

The British-led team of medical researchers identified “four aspects of immune system disturbances that lead to the development of celiac disease” (United Press International).

"We can now shed light on some of the precise immune disturbances leading to coeliac disease. These include how T cells in the body react to toxic wheat proteins, how the thymus gland eliminates these T cells during infancy, and the body's response to viral infections.

"We now understand that many of these genetic risk factors work by altering the amounts of these immune system genes that cells make.


"The data also suggests that coeliac disease is made up of hundreds of genetic risk factors, we can have a good guess at nearly half of the genetic risk at present" (Prof. David van Heel, professor of gastrointestinal genetics at Barts; DNA India; Nature Genetics journal, boldface added).

Toxic wheat proteins…. I’m all for the advancement of science and particularly in medicine, but when our food supply becomes toxic to our own bodies (at least as our body sees it), it is time to stop tampering with what goes into our bodies and start focusing on preventative medicines and treatment, that are both natural and non-toxic, regardless of what levels the FDA deem safe. 

It is good news that the scientific and medical communities are spending the time in research considering celiac disease is becoming so prevalent around the world. According to Reuters, these new findings may help “speed the search for better ways to diagnose and treat the gluten-intolerance disorder” (Reuters.com).

The bad news is that the “study also shows that there is substantial evidence to indicate a shared risk between the gene associated with coeliac disease and many other common chronic immune mediated diseases” including diseases such as type 1 diabetes and rheumatoid arthritis (DNA India, Reuters).

With my own research, I already know that CD is caused by an abnormal immune response to gluten, which can be found in wheat, rye, and barley products and can be hidden just about anywhere —from medicines and vitamins to lip balms and lipsticks. I know that the reaction causes damage to the lining of the small intestine, essentially flattening the villi, which are the tiny, hairlike projections that normally stand upright (mental image: a field of grass moving with the breeze). Each tiny little villi absorbs nutrients which then get absorbed into the blood stream. When the villi are flattened, the body can no longer properly absorb nutrients.... and you may never know it is happening until the damage has already been done.

You may be eating to your heart’s content, but as long as your body cannot receive nutrients on a cellular level, your body will be literally starving to death. This is why the disease affects so many organs and systems in the body—it affects your entire body. You may end up with weakened bones, anemia, chronic fatigue syndrome, weight loss or weight gain, or any one or combination of over 300 symptoms.

In simplest terms for me, gluten is the alien that created crop circles in my gut, substantially reducing my nutrient harvest. There is no cure for it and that the only treatment is a life-long diet free of gluten and avoiding all hidden sources of gluten.  So I have CD.  I live, and I move on.  Do I miss all those bread products and over-processed snacks and addiction to sugar?  Actually.... surpisingly, no.  I don't.  What's to miss?  Horrible stomach pain, a weakened heart, failing organs and a reduced standard of health (i.e., living)?

I think not.  Keep plugging away, researchers!

Saturday, December 26, 2009

Celiac Disease is an Autoimmune Disorder

Celiac disease is an autoimmune disorder. According to the National Institute of Health (NIH), "An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue" (Medline Plus).

In a healthy person, our immune system is protected from harmful substances by white blood cells. That is why when we have an infection, our white blood cell count is elevated. These white blood cells are sent out to destroy the bad guys (antigens like bactiria or viruses or other harmful substances in our body). But if you have an autoimmune disease, like celiac disease, your immune system can no longer tell the difference between what is normal and what is an antigen. So the body sends out the signal to destroy the wrong thing-- in this case it destroys normal body tissue.

This is similar to when the body has an allergic reaction, but with an allergy, the body is reacting to an external substance, while with an autoimmune disorder, the body reacts to normal body tissue.

Nobody really knows what causes the immune system to lose its ability to determine healthy body tissue from antigens, but there seems to be a genetic prospensity that tends to single some people out while ignoring others.

According to the NIH, autoimmune dieseases will manifest various symptoms that are specific to the disease, but there are some that are common, such as:
  • Dizzines
  • Fatigue
  • General ill-feeling
  • Low-grade fever

Celiac disease is a genetic autoimmune disease in which gluten and other proteins (wheat, barley, and rye) damage the lining of the small intestines. There is no cure, and at this point can be treated only through strict dietary measures. Even trace amounts can cause continued damage to the gut, with or without symptoms. This drawing which I borrowed from the Celiac Disease Foundation shows the interior wall of the small intestine. It is lined with tiny hairlike villi which absorb the nutrients from food as it passes through the intestines. Celiac disease flattens these villi, making it more difficult for us to get the nutrients we need, and in turn-- causing a whole host of other problems.

According to an article in The North Jersey News:

"There are three necessary components to celiac... You need to carry the gene that predisposes you to the disease. You need exposure to the gluten, and you need a trigger mechanism. Right now we don’t really know what that trigger might be, but once it’s triggered into action, it doesn’t go away" (North Jersey News, Dec. 1, 2009).

The Celiac Disease Foundation states that "Celiac disease affects more people than all of these disorders combined" and that "97% of people with Celiac Disease go undiagnosed. Celiac Disease is one of the most common genetic conditions in the world. Celiac is a multi-symptom, multi-system disorder, activated by eating gluten - proteins found in wheat, rye and barley. Symptoms vary and are not always gastrointestinal." So just because you aren't having a stomach ache or some other digestive issue, does not necessarily mean you are free from having celiac, especially if you have a family history of digestive troubles.

When in doubt, check it out!